Tri-Luma® Cream

Uncovering a luminous and even skin tone.









Pigmentation and melasma can dull and age your appearance. Fortunately, you don’t have to live with an uneven skin tone. Take action with Tri-Luma, a simple cream that can give you back clear, luminous skin.

Melasma (brown patches or mask of pregnancy) is a condition that affects many women worldwide. Up to 75% of pregnant women and up to 35% of women using birth control pills are affected by melasma.

What is the Tri-Luma® Cream?









Tri-Luma® Cream is an FDA-approved, unique triple-combination topical therapy for the short-term treatment of dark spots associated with moderate-to-severe facial melasma.

It contains 3 active ingredients, combined to safely and effectively improve the look of melasma and other pigmentation issues like freckles and uneven skin tone over time, and help prevent dark patches from forming again.


How does the Tri-Luma® Cream work?

Understanding how the 3 active ingredients in Tri-Luma® work:

  • Tretinoin 0.05%

Accelerates loss of melanin. Melasma is caused by the over-production of the pigment melanin. Tretinoin accelerates skin cell activity and turnover, speeding up the shedding of darkened cells and causing skin to lighten faster.


  • Fluocinolone acetonide 0.01%

Reduces possible irritation caused by tretinoin and hydroquinone. This makes the Tri-Luma cream a safer choice of topical treatment for melasma.


  • Hydroquinone 4%

Inhibits the enzyme (tyrosinase) found in melanocytes to stop melanin over-production. Melanocytes (the melanin-producing cells located in the basal layer of the epidermis) are responsible for increased epidermal pigmentation in melasma. Hydroquinone, diminishes melanin production thus preventing melasma from darkening, spreading, or forming again.

What results can I expect?

Patients experienced improvement of their melasma with the use of Tri-Luma® Cream as early as 4 weeks. After 8 weeks of treatment with Tri-Luma®Cream, most patients had at least some improvement. Some had their dark spots clear up completely (38% in one study and 13% in another). Results vary from person to person.